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KMID : 1025520070490010025
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Journal of Animal Science and Technology
2007 Volume.49 No. 1 p.25 ~ p.32
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Effect of Conjugated Linoleic Acid (CLA) on Proliferation and Differentiation of Porcine Adipocyte and Muscle Cell
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Chung Chung-Soo
Kim Hye-Rim
Kang J. N.
Kim Nae-Su
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Abstract
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The current study was undertaken to determine the effect of conjugated linoleic acid(CLA) isomers, cis-9, cis-11(c9c11), cis-9, trans-11(c9t11), trans-9, trans-11(t9t11), trans-10, cis-12(t10c12) on differentiation of pig preadipocytes and myogenic satellite cells during culture. Cells were isolated from new born pigs. The t10c12 isomer decreased differentiation of pig preadipocytes(92%), but not that of myogenic cells. The t9t11 isomer decreased differentiation of preadipocytes(14%) and increased that of myogenic cells (26%). No other CLA isomers affected differentiation of preadipocytes or myogenic cells. The effects of CLA on proliferation of preadipocytes and myogenic cells were small, compared to the effects on differentiation. These results suggest that CLA isomers have different effects on differentiaton of pig preadipocytes and myogenic cells.
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KEYWORD
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CLA, Pig, Preadipocyte, Myogenic satellite cells, Differentiation
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